Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective Japanese Claims Data Analysis.

Although the results were attenuated in the multivariate analysis and the multivariate HR was not statistically significant, based on the highly significant univariate HR, we speculate that stroke is one of the major risk factors for MACE in patients with UC; subsequent studies are needed to confirm this speculation. 5 Limitations Some limitations are inherent to a retrospective study using a long‐term claims database.

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Furthermore, patients with history of stroke (1.871; 0.508–6.886) had a higher risk of MACE, but this did not reach statistical significance (Table 2 ).

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