Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta-analyses.

Eleven studies analyzed the effect of L‐PRF on pain following extraction; with eight reporting a statistically significant pain reduction, particularly during the first days, 47 , 50 , 51 , 52 , 54 , 58 , 70 , 71 but in three, the pain reduction did not reach statistical significance. 48 , 65 , 68 The post‐extraction consumption of analgesics was recorded in three studies, 50 , 51 , 58 two reporting a statistical reduction when using L‐PRF. 50 , 51 3.4.4 Meta‐analyses Meta‐analyses were performed with papers using the “same parameters” measured at “the same location,” including standard deviations, and with follow‐up periods ranging from 2.5 to 5 months (Figure 4 ). 40 , 43 , 45 , 46 , 54 , 60 , 61 , 64 , 66 , 67 , 68 Papers with a high risk of bias were not included.

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