MiR-3664-3p through suppressing <i>ABCG2, CYP3A4, MCL1,</i> and <i>MLH1</i> increases the sensitivity of colorectal cancer cells to irinotecan.

Similarly, in SW480-R1 and SW480-R2, the fold changes were 1.65 ± 0.071 and 1.97 ± 0.066, respectively, but did not reach statistical significance ( Fig. 4 F). 3.6 MLH1 expression was upregulated in HCT116-R3 and HCT116-R4 compared to the parental cell lines while no changes in MLH1 expression were observed in any of the SW480-derived resistant cell lines The fold changes in MLH1 expression in HCT116-R3 and HCT116-R4 were 2.16 ± 0.06 and 4.99 ± 0.10, respectively, indicating a notable increase compared to the parental HCT116 cells.

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