The Na⁺,K⁺,2Cl^- Cotransporter, Not Aquaporin 1, Sustains Cerebrospinal Fluid Secretion While Controlling Brain K⁺ Homeostasis.

The NKCC1‐mediated K + uptake (the bumetanide‐sensitive 86 Rb + influx) appeared lower upon reduction of the [K + ] in the surrounding aCSF from the basal 2.5 to 1.5 m m (in × 10 3 cpm: 4.21 ± 0.42 in 2.5 m m K + versus 1.75 ± 0.42 in 1.5 m m K + , n = 6 of each), although the difference did not reach statistical significance ( P = 0.15), Figure 4D .

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