Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD).

Sci Rep · 2025 · PMC11810999 · PMID 39929889

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0.0000

closest p · 0.0× alpha

0.0580

boldest claim

The sentences

highly significantp = 8.26e- 12actually significant

STRING protein interaction analysis yielded a highly significant protein-protein interaction (PPI) score (PPI score p = 8.26e- 12 ), suggesting these proteins might directly interact or work together in common pathways (Fig. 1 D).

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showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

Similarly, Rab6b was significantly ( p ≤ 0.05) altered with CT2168 treatment, while Stx8 showed a trend ( p = 0.058).

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