Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice.

Expression levels of genes encoding FGFR1 ( Fgfr1 ) showed a trend toward reduction; while those encoding KLB ( Klb ) and two FGF21 downstream mediators ( Ehhadh , which encodes enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; and Ppargc1a , which encodes PPARG coactivator 1 alpha) were significantly attenuated in male lFgf21 -/- mice (Fig. 2E ).

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