Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase.

The frequency of the USM and Mem II cluster ( R = −0.68, p = 0.046; R = −0.8, p = 0.01, respectively), but not Mem I ( R = −0.17, p = 0.67), showed a significant negative correlation with anti‐CCP2 IgG levels in RA whereas the rNAV population showed a nearly significant positive correlation (Figure S5 ).

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