ISG15-Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans.

Eur J Immunol · 2025 · PMC11811815 · PMID 39931755

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showed a trendno p-value reported

Intriguingly, this demonstrated a gradient pattern of regulation where ISG15.GG‐expressing cells are regulated similar to control A549 cells, cells expressing the ISG15.AA mutants were characterised by higher ISG levels similar to A549‐ISG15 −/‐ cells, but cells expressing the ISG15.ΔGG mutant consistently showed a trend towards an intermediate level of regulation.

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