Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure.

5d ), DNA methylation levels of Pdx1 , Irs1 , and Kcnma1 in the sperm of AE mice were significantly restored to normal conditions by both CR and Met treatments, whereas the restorations of Ptprn2 , Cnr1 , Pclo , and Pde1c followed a similar pattern although did not reach statistical significance (Fig. 8a ; Supplementary Fig.

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