Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain.

Nat Commun · 2025 · PMC11814113 · PMID 39934103

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hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp ~ 10 −7actually significant

Expression and functional characterization FUMA Magma GTEx tissue analysis of the loci significant in the multi-ancestry analysis showed highly significant ( p ~ 10 −7 ) enrichment of eQTLs in Brain and Pituitary tissues (Supplementary Fig. 9 ).

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nominally significantp < 0.05actually significant

Of these 86 variants, 67 replicate at the nominally significant threshold ( p < 0.05) in the current GWAS of MVP-CBP, and 54 replicate at the Bonferroni-corrected threshold (Supplementary Data 12 .

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