α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson's disease.

Although relatively lower Th17 responses were observed in PDD/DLB patients than in PD patients, this did not reach statistical significance.

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Among the 12 cytokines measured, we focused on IL-17A, IL-17F, IL-22, IFN-γ, and IL-13 because they are produced by T cells and showed highly significant fold changes and increased cytokine levels in PBMCs from PD patients compared with the levels from controls (Fig. 1 A, Supplementary Fig. 2B).

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