Altered Sertoli Cell Function Contributes to Spermatogenic Arrest in Dogs with Chronic Asymptomatic Orchitis.

Whereas reduced GDNF and bFGF mRNA and protein expressions in human Sertoli cells have been published in the case of severely disrupted spermatogenesis, Sertoli-cell-only [ 63 ] and NOA [ 31 ] human patients, our study showed a trend toward upregulation of these factors, matching the findings of Jensen et al. in affected men [ 64 ].

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