A randomised, double-blind, placebo-controlled study to determine the analgesic efficacy, safety and tolerability of VPX638 administered topically to painful wounds.

This is certainly the case in ulcer management where local pain can be quite significant, the disease course (time to healing) is quite protracted and systemic opioid prescription rates are high 18 , 46 , 47 despite the very considerable societal pressure on physicians to reduce opioid prescribing.

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