Arginine metabolism is a biomarker of red blood cell and human aging.

Age‐associated decreases in human RBC spermine ( n = 117 subjects) were suggested previously though the findings did not reach statistical significance and no clear trend for spermidine was observed (Elworthy & Hitchcock, 1989 ).

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Highly significant associations (−log10(p) ranging from 20 to 300) were observed for multiple metabolites and genetic regions coding for well‐established rate‐limiting enzymes in cationic amino acid transport and metabolism (Table S1 ).

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