Distinct response to IL-1β blockade in liver- and lung-specific metastasis mouse models of pancreatic cancer with heterogeneous tumor microenvironments.

In contrast, we noted that in the KPC-3403 model, anti-IL-1β monotherapy resulted in a non-significant trend of increase in monocyte/macrophage and a significant trend of increase granulocytes, respectively. anti-PD-1 treatment reduced the percentage of both monocyte/macrophages and granulocytes in the KPC-3403 model.

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