Extracorporeal photopheresis induces the release of anti-inflammatory fatty acids and oxylipins and suppresses pro-inflammatory sphingosine-1-phosphate.

In DHLF-COPD the Mann-Whitney U test showed a highly significant difference in distributions (U = 41246, p = 1.01 × 10 −5 ) and Mood’s Median Test confirmed a significant difference in medians (χ 2 = 15.82, p = 7 × 10 −5 ) comparing control and treatment group while in NHLF no significant correlation could be detected (Fig. 6 A).

also in 132,142 other papers

While the fatty acids arachidonic acid (AA) and docosahexaenoic acid (DHA) as well as the lipid mediators 12-hydroxy-eicosatetraenoic acid (HETE) and 14-hydroxy-docosahexaenoic acid (HDoHE) did not reach statistical significance, they were found to be upregulated upon treatment on both days 1 and 2 (Fig. 3 G, I, J and L).

also in 111,027 other papers