Causal association between serum bilirubin and ischemic stroke: multivariable Mendelian randomization.

For the KCPS-II dataset, the crude 2-sample MR results and the MVMR model adjusted for LDL showed borderline significant results, while the MVMR models controlled for HDL and TG demonstrated significance.

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In each remaining model, a negative association between total bilirubin and ischemic stroke was observed, but it did not reach statistical significance ( Figure 1A ).

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