2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.

Interdiscip Cardiovasc Thorac Surg · 2025 · PMC11826094 · PMID 39949317

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

One study showed that the use of the Hepcon device resulted in a highly significant reduction in the total protamine dose compared to ACT-based dosing (mean protamine dose: 14.190 IU vs 24.777 IU; P < 0.001) and total blood loss (mean blood loss: 804 ml vs 1416 ml; P < 0.001) [ 495 ].

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showed a trendno p-value reported

Data from an observational cohort [ 804 ] from the German Registry for Acute Aortic Dissection Type A, comprising 2100 patients, showed a trend towards a reduction in 30-day mortality associated with the use of mannitol; however, this trend was not statistically significant.

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