However, in females we observe an increasing trend in E / I due to increased excitation from L2/3 and L5/6.
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Sex-Specific Age-Related Changes in Excitatory and Inhibitory Intracortical Circuits in Mouse Primary Auditory Cortex.
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The sentences
We found that the E / I ratio based on density was unchanged in aged females but showed a trend toward excitation ( Fig. 6 A ; L2/3: adult: mean: 0.24, median: 0.20; aged: mean: 0.36, median: 0.35, p KS = 0.036, p Kruskal–Wallis = 0.11.