Usefulness of empiric superior vena cava isolation in paroxysmal atrial fibrillation ablation: a meta-analysis of randomized clinical trials.

The quality of included studies was assessed using the Risk Bias Assessment Tool recommended by the Cochrane Collaboration, as shown in Table A.1 . Clinical outcomes In the overall population SVCI + PVI was associated with a non-significant reduction of AF recurrence at follow-up, although it showed a trend toward efficacy (OR 0.66 [95%CI 0.43;1.00], p -value 0.05, I 2 0%), whereas in patients with paroxysmal AF (PAF), a significant reduction of AF recurrence was related to SVCI + PVI (11.7%) as compared to PVI alone (19.9%), with a pooled OR of 0.54 ([95%CI 0.32;0.92], p -value 0.02, I 2 0%) (Fig. 1 ).

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