BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress.

Nat Commun · 2025 · PMC11832743 · PMID 39962064

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A single injection of the Vitamin D analog calcidiol, which enhances heart regeneration 25 , increased the fraction of mitotic phospho-Histone H3+ (pH3) wound border CMs at 7 dpi and resulted in a strong trend towards an increase in the fraction of γH2a.x+ CMs as well (Supplementary Fig. 3A, B ). mTOR signaling represents one of the pathways required for CM cycling during zebrafish heart regeneration 26 .

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