Cooperative Hedgehog/GLI and JAK/STAT signaling drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer.

Cell Commun Signal · 2025 · PMC11834474 · PMID 39962447

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

a clear trendno p-value reported

We fitted a linear model with an interaction effect between the HH/GLI and IL6/STAT3 effects and observed a clear trend for a synergistic regulation albeit without reaching statistical significance (Fig. 6 G, H).

also in 19,460 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.