Long-Term Dynamics of CSF and Serum Neurofilament Light Chain in Adult Patients With 5q Spinal Muscular Atrophy Treated With Nusinersen.

Neurology · 2025 · PMC11837849 · PMID 39946662

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did not reach statistical significanceno p-value reported

Clinical scores were higher for T5–T8 (Δ HFMSE, 0.6 [CI 0.1–1.4], p = 0.017; Δ RULM, 0.9 [CI 0.4–1.3], p < 0.001; Δ ALSFRS-R, 0.7 [CI 0.4–1.0], p < 0.001) but did not reach statistical significance for the remaining treatment intervals when compared with those of the loading phase ( Table 3 ).

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