Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters.

Front Immunol · 2025 · PMC11841495 · PMID 39981227

Europe PMC DOI

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0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

a statistical trendP=0.056so close (0.05 < p ≤ 0.1)

Though a statistical trend due to the small number of animals (P=0.056 for gRNA and replicating virus titers, and P=0.095 for sgRNA), the hamsters in the recipient group housing with group 2 consistently had a log or two lower median gRNA, sgRNA, and replicating viral load levels in the lungs and oral swabs than those housed with group 1 ( Figure 3D ).

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a strong trendp = 0.056so close (0.05 < p ≤ 0.1)

This difference was significant for BA.5 (p = 0.032), BN.1 (p = 0.0079), BQ.1 (p = 0.032), BQ1.1 (p = 0.016), XBB.1(P=0.032), and a strong trend for WT (p = 0.056), BA.1 (p = 0.056), and BF.7 (p=0.056).

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