Proteomic Comparison of Acute Myeloid Leukemia Cells and Normal CD34⁺ Bone Marrow Cells: Studies of Leukemia Cell Differentiation and Regulation of Iron Metabolism/Ferroptosis.

Even though all six patients with the favorable inv(16) karyotype were localized in various subclusters among the left 40 patients, this difference did not reach statistical significance.

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Variation of the Biological Context of Transferrin and Transferrin Receptors That Are Both Differentially Abundant When Comparing Normal and Leukemic Hematopoietic Cells; Identification of a Patient Minority Whose AML Cells Show Similarities with Normal Cells in Regulation of Cellular Iron Utake Our statistical comparison of primary AML cells and normal CD34 + bone marrow cells showed that both transferrin and the transferrin receptor were differentially abundant with low levels in the leukemic cells; transferrin was then the protein with the lowest p -value and its receptor also showed a highly significant decrease ( Figure 4 , Table S2 ).

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