HEIDI results indicated that 10 of the 37 genes may be significant due to linkage disequilibrium, while 27 were consistent with pleiotropy or causal relationships (Supplementary Table S1 in S1 File ).
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Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.
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The TWAS revealed that 20 of these 28 genes had nominally significant associations with intelligence at the cis-regulated mRNA level, with 10 of these genes showing consistent directionality of effects on both mRNA and protein levels.