Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

Hepatol Int · 2025 · PMC11846769 · PMID 39961976

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a decreasing trendno p-value reported

an increasing trendno p-value reported

8 ) [ 1 , 5 , 146 , 147 ] DILI, autoimmune, and nonalcoholic steatohepatitis etiologies have shown an increasing trend; however, HAV/HEV/HCV showed a decreasing trend [ 101 ].

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did not reach statistical significanceno p-value reported

A systematic review and meta-analysis, including 20 studies and 5705 patients with ACLF, reported improved 30 (RR 1.36, 95% CI 1.22–1.52, p < 0.001) and 90-day (RR, 1.21, 95% CI 1.10–1.34, p < 0.001) survival but did not reach statistical significance on sensitivity analysis including only RCTs [ 228 ].

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