CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus.

The relative increase in Tgfb2 expression at 4 weeks did not reach statistical significance (FDR = 0.09417). 3.7 Distinct upregulation of genes involved in NOD-like receptor signaling in Cd38 -/- PECs vs WT PECs during cGVHD induction To note is that 14 pathways were exclusively enriched in WT PECs and not in Cd38 -/- PECs, including Ras signaling pathway, NOD-like receptor signaling pathway, fatty acid metabolism and the PI3K-Akt signaling pathway ( Figure 5D ).

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