Responses of B-type natriuretic peptide (BNP), mature BNP and proBNP to sacubitril/valsartan differs between responders and non-responders.

Open Heart · 2025 · PMC11848661 · PMID 39988342

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did not reach statistical significanceno p-value reported

Both ANP and mature BNP are substrates for neprilysin, but while ANP increased significantly after Sac/Val administration, increases in mature BNP did not reach statistical significance.

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