The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources.

Using this filtration strategy that leveraged the epigenomic data derived from the CMDGA, the Variant Sifter tool returned 79 variants, including one variant (chr9:504,491:A>C) demonstrating an association with ALS based on the meta-analysis of NDKP data that is approaching significance (β = 0.238, p = 7.01e-4; Figure 6D ).

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27 The bottom-line analysis can both identify novel associations that are not significant at the level of individual datasets but become significant when multiple studies are considered and identify artifactual associations that may be significant in one dataset but are not replicated in others using a fixed-effect method.

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