Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in <i>EGFR</i>-Mutated Lung Adenocarcinoma.

JTO Clin Res Rep · 2025 · PMC11850751 · PMID 40007550

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Similarly, high-podoplanin (n = 31) versus low-podoplanin (n = 62) expression in CAFs was not associated with worse disease-free survival after surgery ( p = 0.65), but was significantly associated with worse PFS and showed a trend towards worse overall survival following osimertinib treatment ( p < 0.001, p = 0.11).

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