Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells.

Nucleic Acids Res · 2025 · PMC11851107 · PMID 39997223

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highly significantno p-value reported

Overall, MERVL-int and MT2_Mm showed highly significant decrease in locus-specific mean CpG methylation levels and increase in locus-specific transcript levels in Dnmt1 INV and Dnmt1 RES compared to Dnmt1 CTL (Fig. 5D – G and Supplementary Table S5 ).

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approached significanceno p-value reported

While the permanent increase pattern of H3K27ac displayed neutral association, it approached significance for positive association.

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