Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns.

ACS Chem Biol · 2025 · PMC11851433 · PMID 39824511

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a clear trendno p-value reported

33 The initial HTS hit, compound 1 , possessed a moderate K i (27 ± 6 μM), and subsequent SAR optimization revealed a clear trend between the electronics of the amino-aromatic substituent and intron binding.

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