Exploratory analysis of biological age measures in a remyelination clinical trial.

In contrast, although CA had no effect on brainstem remyelination in response to bexarotene (reduction by 0.01 pu/year, CI [−0.08, 0.09], P = 0.88), increasing baseline BA MRI was associated with a borderline significant decrement in brainstem remyelination (reduction by 0.06 pu/year in adjusted model, CI [0.00, 0.13], P = 0.058).

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A negative trend was also seen for BA Blood in brainstem remyelination (reduction by 0.02 pu/year in adjusted model, CI [−0.01, 0.05], P = 0.17).

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Whilst there was a slight trend towards GM preservation in the bexarotene group—consistent with the beneficial effect on BA MRI —this was not statistically significant (+247 mm 3 [CI: −3343, 3838], P = 0.89).

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