IL-1ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology.

Mol Ther · 2025 · PMC11853362 · PMID 39673131

Europe PMC DOI

hedged sentence

0.0645

closest p · 1.3× alpha

0.0645

boldest claim

The sentences

nearly significantp = 0.0645so close (0.05 < p ≤ 0.1)

C1q transcripts were again significantly reduced in the SMA IL1ra/CCL5NAb condition compared to UTX ( Figure 3 D; one-way ANOVA, ∗ p = 0.0123), whereas C3 transcripts were significantly reduced with IL1ra/CCL5NAb (∗∗ p = 0.0031) and had a nearly significant reduction in the 48-h wash condition ( p = 0.0645).

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