Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

28 An MYOC exon 3 variant (rs74315329; effect allele: A) was associated with a 1.63 mm Hg (95% confidence interval [CI] = 0.64 to 2.64) and 2.67 mm Hg (95% CI = 1.7 to 3.60) increased IOP in participants <51 years old and ≥63 years old, respectively, resulting in a nominally significant age-gene interaction ( P interaction = 0.05; Supplementary Table S10 ).

also in 7,732 other papers

The interaction test between the mtGPRS and continuous age for IOP was highly significant ( P interaction = 2.7e-27).

also in 132,142 other papers