Plasma attenuates endothelial injury compared to crystalloids in a ventilated rat pneumosepsis model.

PLoS One · 2025 · PMC11856581 · PMID 39999161

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Animals resuscitated with plasma showed a trend towards lower syndecan-1 levels compared to the standard-volume crystalloid group (82 vs 99 ng/mL, p = 0.06) and had lower levels of VCAM-1 (424 vs 592 ng/mL, p < 0.01) compared to the standard volume crystalloid group, but not when compared to the low-volume crystalloid group.

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