Is <i>N</i>1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker?

In contrast, dolutegravir exhibited the opposite effect to other OCT inhibitors, with NMN plasma concentrations showing an increasing trend across all time intervals [ 14 ].

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Relative to baseline, the pharmacokinetic measurements of NMN showed a trend of reduction in plasma exposure and C max following OCT inhibitor treatment in healthy adults ( Table 1 ).

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