Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice.

Increased spare capacity in AA-treated WT and 5xFAD female mice approached but did not reach significance ( Figure 5 D; χ 2 = 7.57, p = 0.06).

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There was, however, a statistically significant increase following AA treatment in spare capacity ( Figure 5 H; χ 2 = 8.03, p = 0.045) and a borderline significant increase in maximal respiration ( Figure 5 F; χ 2 = 7.44, p = 0.06) in 5xFAD male mice.

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There was also a significant trend towards diminished maximal respiration evident in female 5xFAD mice that was likewise significantly increased in AA-treated 5xFAD female mice ( Figure 5 B; χ 2 = 15.69, p = 0.001).

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