Association of <i>OPRM1</i> and <i>OPRD1</i> Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer.

Pharmaceuticals (Basel) · 2025 · PMC11860135 · PMID 40006034

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0544

boldest claim

The sentences

highly significantp < 2 −16actually significant

A highly significant difference in allelic frequencies was observed across all analyzed polymorphisms (chi-squared test, p < 2 −16 ).

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a trend toward significancep = 0.0504so close (0.05 < p ≤ 0.1)

For OPRM1 rs510769, the dominant model showed a significant association with pain severity ( p = 0.033), while the overdominant model revealed a trend toward significance ( p = 0.0504).

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showed a trendp = 0.0544so close (0.05 < p ≤ 0.1)

CT) showed a trend toward significance ( p = 0.0544), indicating a potential difference in the pain severity for individuals with the CT genotype compared to those with CC or TT genotypes ( Figure 3 C).

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