Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant.

Sci Adv · 2025 · PMC11864192 · PMID 40009690

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showed a trendno p-value reported

In contrast, individuals with low IgG titers showed a trend of reduced FcγRIIa binding following depletion, supporting previous observations that IgG4 can work in synergy with other subclasses to improve FcγRIIa binding.

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