Lastly, along with the downregulation of PSGL1, the expression of Bcl-6, the master regulator of Tfh cell differentiation 74 , was also increased in the PD-1 + fraction in OT-II cells and showed a trend for an increase in endogenous CD4 + T cells in CD301b ΔIL-2 mice (Fig. 7k–n ), further suggesting that more CD4 + T cells are poised for Tfh differentiation in these mice.
← all excerpts
CD301b<sup>+</sup> dendritic cell-derived IL-2 dictates CD4<sup>+</sup> T helper cell differentiation.
1
—
—