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Independent genetic strategies define the scope and limits of CDKL5 deficiency disorder reversal.

Cell Rep Med · 2025 · PMC11866500 · PMID 39855191

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There was a trend visible in the data for both Cdkl5 STOP ( Figure 3 J) and Cdkl5 FLEX ( Figure 4 J) lines, suggesting that Res mice performed somewhere in between WT and STOP or FLEX mice during the rotarod assay, though increased latency to fall of Res relative to STOP mice did not reach statistical significance in most trials.

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