Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations.

We found that having had a symptomatic infection before inclusion in the study negatively associated with the abundance of differentiated CD4 + T cells and baseline CD4 + T cell activation but was not associated with weaker vaccine responses and only showed a trend toward reduced antigen-specific CD4 + FS ( Figure 7 F).

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