Serum levels of hepatitis B core antibodies and hepatitis B core-related antigen at the time of nucleos(t)ide analog cessation and risk of severe flares in patients with chronic hepatitis B.

Hepatol Commun · 2025 · PMC11868428 · PMID 40008890

Europe PMC DOI

hedged sentences

0.0564

closest p · 1.1× alpha

0.0564

boldest claim

The sentences

did not reach statistical significancep =0.0564so close (0.05 < p ≤ 0.1)

When adjusting for anti-HBc IgG, HBcrAg undetectable did not reach statistical significance in the multivariate analysis but still provided strong OR of 7.150 (95% CI, 1.161–80.166; p =0.0564) and 3.751 (95% CI, 0.639–22.017; p =0.1431), respectively.

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a numerical trendno p-value reported

30 In our study of mostly European, HBV genotype A/D, long-term virologically suppressed, HBeAg-negative patients, we observed no association between EOT anti-HBc IgG levels and “milder” HBV DNA relapse, a numerical trend with biochemical flares of any type and, for the first time, demonstrated that severity of off-treatment virologic relapse and biochemical flare is significantly associated with low EOT anti-HBc IgG levels and low but detectable HBcrAg levels.

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a weak trendno p-value reported

There was a weak trend for correlation ( R 2 =0.189, p value 0.0045) between EOT HBV RNA levels and anti-HBc IgG levels, mainly due to 7 of 8 patients with EOT HBV RNA levels <LLOQ (detectable or TND) also having low anti-HBc IgG levels (Supplemental Figure S4, http://links.lww.com/HC9/B907 ).

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