EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy.

iScience · 2025 · PMC11872638 · PMID 40034852

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showed a trendno p-value reported

In addition, NPPA , GABARAPL2 , and ADM showed a trend toward upregulation in the mutant cardiomyocytes but no significant response to NAC-mediated ROS elimination ( Figure 3 M).

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a decreasing trendno p-value reported

Notably, NPPB and GADD45A showed significant restoration to physiological levels upon EPAS1 downregulation, either through ROS elimination or siRNA-mediated knockdown in the DSP mutant cells, while the other genes exhibited a decreasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.