Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases.

In a recent study, the abundance of phylum Firmicutes , class Clostridia , order Clostridiales , family Ruminococcaceae , and genus Faecalibacterium in fecal samples all showed a trend towards a progressive decline when comparing normal control patients with individuals with subjective cognitive decline (SCD), the earliest symptomatic manifestation of preclinical Alzheimer’s disease, and cognitive impairment [ 142 ].

also in 53,322 other papers

Similarly, a follow-up study examining upper jejunal biopsy sections from 10 (well-nourished) elderly patients (aged 60–73) and 10 specimens from younger patients (aged 16–30) found there was a highly significant reduction in mucosal surface area in elderly patients [ 174 ] (Table 1 ).

also in 132,142 other papers