Association between adult education, brain volume and dementia risk: longitudinal cohort study of UK Biobank participants.

In 499,337 participants aged between 40 and 69 at baseline with 13.2 years mean follow-up, in analyses adjusted for age, sex, education, deprivation, ethnicity, hypertension, diabetes, ethnicity, obesity, smoking, alcohol use, physical inactivity and social isolation, we replicated previous findings of a protective effect of adult education on dementia risk (HR 0.82, 95% CI 0.74–0.90, P < 0.001), and showed a trend towards protection against dementia if adult education was continued rather than intermittent.

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