[<sup>18</sup>F]FDG-PET and [<sup>18</sup>F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation.

Sci Rep · 2025 · PMC11873236 · PMID 40025148

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0.0709

closest p · 1.4× alpha

0.0709

boldest claim

The sentences

a strong trendp = 0.0709so close (0.05 < p ≤ 0.1)

Quantitative analysis of [ 18 F]MPPF uptake in the brain was increased in mice lacking functional Slc6a8 with a strong trend towards statistical significance ( p = 0.0709; WT, 0.304 ± 0.066%ID/cc, n = 13; Slc6a8 -/y , 0.358 ± 0.073%ID/cc, n = 11) (Fig. 8 A).

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not quite statistically significantno p-value reported

Though not quite statistically significant, this data indicates a potential impairment of contextual fear memory in the mutant mice.

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