Characterization of the role of spatial proximity of DNA double-strand breaks in the formation of CRISPR-Cas9-induced large structural variations.

Although we did not reach statistical significance when replicating the experiment in another cell line, H9 hESCs ( Fig. 2 B), it is possible that the observed effect in K562 cells also applies to other cell lines, as the replicate analysis was underpowered and limited by significantly lower Hi-C interaction strength between sgRNA pairs in the proximity group compared with K562 cells ( Supplemental Fig.

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However, the observed differences were only borderline significant, so we did not interpret the evidence to be conclusive.

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